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Scale-Up of Integrated Biorefineries and Greenhouse Gas Reduction in First Generation Ethanol Production (Scale-Up+)

Federal Agency


Bioenergy Technologies Office (BETO)


To support high-impact technology RD&D to accelerate the bioeconomy and, in particular, the production of low-carbon fuels for the aviation, marine, rail, and long-haul trucking industries; to strengthen current first generation (Gen-1) corn ethanol production facilities by reducing their overall carbon footprint.

Applicant and/or Project Eligibility Requirements

Broad eligibility for groups, governments, individuals, and consortia of the above, including alllowances for foreign entities. BETO is interested in the following Topic Areas: - TA 1: Pre-Pilot Scale-Up of Integrated Biorefineries - TA 2: Pilot Scale-Up of Integrated Biorefineries - TA 3: Demonstration Scale-Up of Integrated Biorefineries - TA 4: Gen-1 Corn Ethanol Emission Reduction

Decarbonization Considerations

BETO focuses on developing technologies that convert domestic lignocellulosic biomass and waste resources into affordable low-carbon biofuels and bioproducts that significantly reduce carbon emissions on a life-cycle basis as compared to equivalent petroleum-based products. By reducing cost and technicl risk, BETO helps the industry deploy commercial-scale integrated biorefineries and reduce greenhouse gas emissions from hard-to-decarbonize sectors, such as the aviation industry. This FOA will support the Biden Administration’s new action items to produce 3 billion gallons of sustainable aviation fuel (SAF) per year and reduce aviation emissions by 20% by 2030 towards unlocking the potential for a fully zero-carbon aviation sector by 2050.

Equity Considerations

Applicants are required to submit a Diversity, Equity, and Inclusion Plan that describes the actions the applicant will take to foster a welcoming and inclusive environment, support people from underrepresented groups in STEM, advance equity, and encourage the inclusion of individuals from these groups in the project; and the extent the project activities will be located in or benefit underserved communities.

Helpful Tips

BETO is focusing on applied RD&D to improve the performance and reduce cost of biofuel production technologies and scale-up production systems in partnership with industry. BETO is focused on developing and demonstrating technologies that are capable of producing low-carbon, cost-effective biofuels and co-products by 2030, as well as biofuel production pathways that can deliver at least 70% lower lifecycle greenhouse gas emissions than petroleum.

Other Notes


Deadline (Announced or Anticipated)

July 8, 2022 (Concept Paper); September 9, 2022 (Full Application)

Funding Available


Max Award Amount


Expected Allocations


Average Award (Estimated)

Varies by subtopic

Matching Funds

20-50% cost share, depending on subtopic

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